A Comparative Analysis of Advanced Convolutional Neural Network Architectures for Osteoporosis Detection from Medical Images
DOI:
https://doi.org/10.15662/IJEETR.2026.0802021Keywords:
Osteoporosis, Deep Learning, Medical Imaging, Convolutional Neural Networks, ResNet18Abstract
Osteoporosis is a common skeletal condition that reduces bone strength and increases the risk of fractures, especially among women above the age of forty and older adults. Early detection plays an important role in preventing severe complications, yet access to standard diagnostic methods is often limited in many regions. With the growing use of medical imaging and artificial intelligence, deep learning models have shown promising results in automated disease classification. This paper presents a comparative study of four advanced convolutional neural network models for multi class osteoporosis detection using bone X ray and dexa images. The dataset consists of 1186 images categorized into Normal, Osteopenia, and Osteoporosis classes. VGG16, DenseNet121, InceptionV3, and ResNet18 were trained and evaluated under the same experimental conditions using transfer learning. Performance was measured using accuracy, precision, recall, and F1 score. Among the evaluated models, ResNet18 achieved the best overall performance with an accuracy of 90 percent. The results indicate that residual network architectures provide reliable feature representation while maintaining computational efficiency, making them suitable for practical osteoporosis screening applications
References
1. K. Suzuki, “Overview of deep learning in medical imaging,” Radiological Physics and Technology, vol. 10, pp. 257–273, 2017.
2. J. A. Kanis et al., “Osteoporosis,” The Lancet, vol. 397, no. 10269, pp. 209–221, Jan. 2021.
3. T. Fang et al., “Deep CNN based feature extraction for osteoporosis classification using X-ray images,” Biomedical Signal Processing and Control, vol. 63, p. 102158, Mar. 2021.
4. G. Litjens et al., “A survey on deep learning in medical image analysis,” Medical Image Analysis, vol. 65, p. 101796, Oct. 2020.
5. G. M. Blake and I. Fogelman, “The role of DXA bone density scans in the diagnosis and treatment of osteoporosis,” Clinical Radiology, vol. 75, no. 6, pp. 403–410, Jun. 2020.
6. M. Lyu, T. Yin, X. Ye and H. Chen, “Deep learning for bone fracture detection: A comparative study,” Journal of Digital Imaging, vol. 33, pp. 1596–1609, Dec. 2020.
7. S. Wang et al., “Quantitative ultrasound and deep learning based osteoporosis screening using heel images,” IEEE Journal of Biomedical and Health Informatics, vol. 24, no. 5, pp. 1410–1418, May 2020.
8. C.Nagarajan and M.Madheswaran - ‘Stability Analysis of Series Parallel Resonant Converter with Fuzzy Logic Controller Using State Space Techniques’- Taylor &Francis, Electric Power Components and Systems, Vol.39 (8), pp.780-793, May 2011. DOI: 10.1080/15325008.2010.541746
9. C.Nagarajan and M.Madheswaran - ‘Experimental verification and stability state space analysis of CLL-T Series Parallel Resonant Converter’ - Journal of Electrical Engineering, Vol.63 (6), pp.365-372, Dec.2012. DOI: 10.2478/v10187-012-0054-2
10. C.Nagarajan and M.Madheswaran - ‘Performance Analysis of LCL-T Resonant Converter with Fuzzy/PID Using State Space Analysis’- Springer, Electrical Engineering, Vol.93 (3), pp.167-178, September 2011. DOI 10.1007/s00202-011-0203-9
11. S.Tamilselvi, R.Prakash, C.Nagarajan,“Solar System Integrated Smart Grid Utilizing Hybrid Coot-Genetic Algorithm Optimized ANN Controller” Iranian Journal Of Science And Technology-Transactions Of Electrical Engineering, DOI10.1007/s40998-025-00917-z,2025
12. S.Tamilselvi, R.Prakash, C.Nagarajan,“ Adaptive sliding mode control of multilevel grid-connected inverters using reinforcement learning for enhanced LVRT performance” Electric Power Systems Research 253 (2026) 112428, doi.org/10.1016/j.epsr.2025.112428
13. S.Thirunavukkarasu, C. Nagarajan, 2024, “Performance Investigation on OCF and SCF study in BLDC machine using FTANN Controller," Journal of Electrical Engineering And Technology, Volume 20, pages 2675–2688, (2025), doi.org/10.1007/s42835-024-02126-w
14. C. Nagarajan, M.Madheswaran and D.Ramasubramanian- ‘Development of DSP based Robust Control Method for General Resonant Converter Topologies using Transfer Function Model’- Acta Electrotechnica et Informatica Journal , Vol.13 (2), pp.18-31,April-June.2013, DOI: 10.2478/aeei-2013-0025.
15. C.Nagarajan and M.Madheswaran - ‘DSP Based Fuzzy Controller for Series Parallel Resonant converter’- Springer, Frontiers of Electrical and Electronic Engineering, Vol. 7(4), pp. 438-446, Dec.12. DOI 10.1007/s11460-012-0212-0.
16. C.Nagarajan and M.Madheswaran - ‘Experimental Study and steady state stability analysis of CLL-T Series Parallel Resonant Converter with Fuzzy controller using State Space Analysis’- Iranian Journal of Electrical & Electronic Engineering, Vol.8 (3), pp.259-267, September 2012.
17. C.Nagarajan and M.Madheswaran, “Analysis and Simulation of LCL Series Resonant Full Bridge Converter Using PWM Technique with Load Independent Operation” has been presented in ICTES’08, a IEEE / IET International Conference organized by M.G.R.University, Chennai.Vol.no.1, pp.190-195, Dec.2007
18. Suganthi Mullainathan, Ramesh Natarajan, “An SPSS and CNN modelling based quality assessment using ceramic materials and membrane filtration techniques”, Revista Materia (Rio J.) Vol. 30, 2025, DOI: https://doi.org/10.1590/1517-7076-RMAT-2024-0721
19. M Suganthi, N Ramesh, “Treatment of water using natural zeolite as membrane filter”, Journal of Environmental Protection and Ecology, Volume 23, Issue 2, pp: 520-530,2022
20. X. Li et al., “A benchmark for knee bone segmentation and classification in X-ray imaging using deep learning,” IEEE Access, vol. 8, pp. 153196–153207, 2020.
21. H. R. Roth et al., “Application of deep learning to osteoporotic fracture detection in spine CT,” European Journal of Radiology, vol. 109, pp. 128–134, Jan. 2019.
22. T. Zhou, P. R. Baxter, S. B. Kay, and I. B. Ayed, “Weakly supervised deep learning for medical image classification,” IEEE Transactions on Medical Imaging, vol. 37, no. 11, pp. 2539–2548, Nov. 2018.
23. L. Zhang, L. Zhang and B. Du, “Deep learning for bone age assessment: A survey and evaluation,” Computers in Biology and Medicine, vol. 105, pp. 36–52, Nov. 2018.
24. A. Esteva et al., “Dermatologist-level classification of skin cancer with deep neural networks,” Nature, vol. 542, pp. 115–118, Feb. 2017.
25. D. Shen, G. Wu, and H.-I. Suk, “Deep learning in medical image analysis,” Annual Review of Biomedical Engineering, vol. 19, pp. 221–248, 2017.
26. G. Huang, Z. Liu, L. van der Maaten, and K. Q. Weinberger, “Densely connected convolutional networks,” in Proc. IEEE Conf. Computer Vision and Pattern Recognition (CVPR), 2017, pp. 4700–4708.
27. C. Szegedy, V. Vanhoucke, S. Ioffe, J. Shlens, and Z. Wojna, “Rethinking the inception architecture for computer vision,” in Proc. IEEE Conf. Computer Vision and Pattern Recognition (CVPR), 2016, pp. 2818–2826.
28. K. He, X. Zhang, S. Ren, and J. Sun, “Deep residual learning for image recognition,” in Proc. IEEE Conf. Computer Vision and Pattern Recognition (CVPR), 2016, pp. 770–778.
29. M. Tajbakhsh et al., “Convolutional neural networks for medical image analysis: Full training or fine-tuning?” IEEE Transactions on Medical Imaging, vol. 35, no. 5, pp. 1299–1312, May 2016.
30. H. Greenspan, B. van Ginneken, and R. M. Summers, “Guest editorial: Deep learning in medical imaging,” IEEE Transactions on Medical Imaging, vol. 35, no. 5, pp. 1153–1159, May 2016.
31. X. Wang et al., “Deep learning for identifying metastatic breast cancer,” in Proc. IEEE Conf. Computer Vision and Pattern Recognition (CVPR), 2016, pp. 642–650.
32. K. Simonyan and A. Zisserman, “Very deep convolutional networks for large-scale image recognition,” in Proc. Int. Conf. Learning Representations (ICLR), 2015.
33. M. Orellana, F. Perez, and R. Wagner, “Monitoring body image representation in advertisements using computer vision: An exploration of gender disparities,” SSRN Electronic Journal, 2024
34. Y. Zhang, S. Wang, and L. Zhang, “Semantic segmentation of remote sensing images using transfer learning and deep convolutional neural network with dense connection,” IEEE Access, vol. 8, pp. 123–134, Jun. 2020, doi:10.1109/ACCESS.2020.3003914.
35. M. Rashid, M. A. Khan, M. Alhaisoni, S. H. Wang, S. R. Naqvi, A. Rehman, et al., “A sustainable deep learning framework for object recognition using multi-layers deep features fusion and selection,” Sustainability, vol. 12, no. 12, p. 5037, 2020.
36. Y. Dang, F. Duan, and J. Chen, “Oil-painting style classification using ResNet with conditional information bottleneck regularization,” Entropy, vol. 27, no. 7, p. 677, Jun. 2025.





